While small and island nations are among the most vulnerable to climate change, they are also among the most important sources of leadership, innovation and inspiration for climate and health action worldwide. Their experiences offer valuable lessons for all countries seeking to build healthier, more resilient and sustainable futures. Building on the Call to action of the Pan-European Commission on Climate and Health (PECCH), this event organized by WHO/Europe will bring together leaders and experts from the Pacific, European, Caribbean, and African regions to explore how countries most exposed to climate risks are turning ambition into action. Through lived experiences, national and regional perspectives, the session will examine how health can serve as a powerful entry point for accelerating climate action. The discussion will showcase practical solutions that are protecting populations, strengthening preparedness, reducing vulnerability and supporting sustainable development. It will also explore opportunities to scale impact through stronger partnerships and cross-regional collaboration.