Drawing on the CLIMOS Risk Factor Analysis (Danyang et al., 2026; available online at RFA), which examined 700 socio-economic, climatic, and environmental variables, this brief translates evidence from multiple interacting variables into a policy-oriented framework for interpreting leishmaniasis risk. The findings suggest that no single driver dominates across settings: socioeconomic and vulnerabilityrelated factors are often central, climate contributes variably, and risk profiles differ between and within countries. Rather than ranking factors or producing predictions, this framework supports structured interpretation of risk to guide targeted prevention.